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Isoforskolin

Cat. No. M4715
Isoforskolin Structure
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5mg USD 450  USD450 In stock
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Biological Activity

Isoforskolin

Chemical Information
Molecular Weight 410.5
Formula C22H34O7
CAS Number 64657-21-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chuang Xiao, et al. Isoforskolin, an adenylyl cyclase activator, attenuates cigarette smoke-induced COPD in rats

[2] Chuang Xiao, et al. Isoforskolin Alleviates AECOPD by Improving Pulmonary Function and Attenuating Inflammation Which Involves Downregulation of Th17/IL-17A and NF-κB/NLRP3

[3] Yun Peng, et al. Isoforskolin and Cucurbitacin IIa promote the expression of anti-inflammatory regulatory factor SIGIRR in human macrophages stimulated with Borrelia burgdorferi basic membrane protein A

[4] Tingting Feng, et al. Pharmacokinetics of isoforskolin after administration via different routes in guinea pigs

[5] Weimin Yang, et al. Isoforskolin pretreatment attenuates lipopolysaccharide-induced acute lung injury in animal models

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