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IPI3063

Cat. No. M6307
IPI3063 Structure
Size Price Availability
5mg USD 240 4-7 Days
10mg USD 400 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

In vitro: IPI-3063 is a p110δ selective compound with an IC50 = 0.1 nM in p110δ-specific cell-based assays and cellular IC50 values for the other class I PI3K isoforms are at least 1,000-fold higher. IPI-3063 potently reduces mouse B cell proliferation, survival, and plasmablast differentiation.

In vivo: IPI-3063 has good pharmacokinetics in mice.

Protocol
Cell Experiment
Cell lines purified mouse B cells
Preparation method Purified mouse B cells are incubated for 48 h in either B-cell activating factor (BAFF) or interleukin-4 (IL-4) with various concentrations of IPI-3063 and IPI-443.
Concentrations 0.01, 0.1, 1, 10, 30, 100 nM
Incubation time 48 h
Animal Experiment
Animal models Brown Norway rats
Formulation 0.5% carboxymethylcellulose, 0.05% Tween 80 in ultra-pure water
Dosages 50 mg/kg
Administration oral administration
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 455.51
Formula C25H25N7O2
CAS Number 1425043-73-7
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation.
Chiu H, et al. Front Immunol. 2017 Jun 30;8:747. PMID: 28713374.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: IPI3063 supplier, PI3K, inhibitors

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