Free shipping on all orders over $ 500

IOX1

Cat. No. M6831
IOX1 Structure
Synonym:

IOX 1

Size Price Availability Quantity
10mg USD 100 In stock
50mg USD 350 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

IOX1 is a histone demethylase JMJD inhibitor (IC50 values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). IOX1 inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 189.17
Formula C10H7NO3
CAS Number 5852-78-8
Purity >98%
Solubility DMSO: 15 mg/mL (Need ultrasonic and warming)
Storage at -20°C
References

A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1.
Schiller R, et al. ChemMedChem. 2014 Mar;9(3):566-71. PMID: 24504543.

Related Histone demethylases Products
GSK-J5

GSK-J5 is a cell-permeable, inactive control for histone demethylase JMJD3/UTX inhibitor GSK-J4.

QC6352

QC6352 is a potent KDM4C inhibitor.

CPI-455 HCl

CPI-455 HCl is a potent and selective inhibitor of KDM5 demethylases which reduces survival of drug-tolerant cancer cells, with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays.

Daminozide

Daminozide is a selective KDM2/7 inhibitor.

CP2

CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: IOX1, IOX 1 supplier, Histone demethylases, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.