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  Catalog
Abmole Inhibitor Catalog 2017

Histone demethylases Histone demethylases

Inhibitors

Cat.No.  Name Information
M5229 EPZ020411 EPZ020411 is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has >10 fold selectivity for PRMT6 over PRMT1 and PRMT8. IC50 value: 10 nM
M5213 ORY-1001 ORY-1001 (RG-6016) is the only dual KDM1A/LSD1 inhibitor, and it is also the only KDM1A inhibitor in development for the treatment of neurodegenerative disease.
M5212 GSK2879552 GSK2879552 is a potent, selective, orally bioavailable, mechanism-based irreversible inactivator of LSD1.
M5149 GSK-J4 GSK-J4 is a cell permeable procompound rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor.
M5136 GSK-LSD1 GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B).
M2275 JIB-04 JIB-04 is a selective inhibitor of Jumonji histone demethylase with IC50 values of 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively.


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