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QC6352

Cat. No. M9375
QC6352 Structure
Size Price Availability
5mg USD 570 4-7 Days
10mg USD 940 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

QC6352 is a potent KDM4C inhibitor. QC6352 blocks proliferation and self-renewal of BCSCs.

In vivo, QC6352 strongly affects tumor growth and final tumor weight of both BCSC1 and BCSC2 xenografts. Treatment with QC6352 is well tolerated and does not affect body weight of the mice. Results demonstrate that treatment with the KDM4 inhibitor QC6352 blocks BCSC xenograft tumor growth.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 387.47
Formula C24H25N3O2
CAS Number 1851373-36-8
Purity >98%
Solubility DMSO ≥ 15 mg/mL
Storage at -20°C
References

KDM4 Inhibition Targets Breast Cancer Stem-like Cells.
Metzger E, et al. Cancer Res. 2017 Nov 1;77(21):5900-5912. PMID: 28883001.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: QC6352 supplier, Histone demethylases, inhibitors

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