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Cat. No. M3691
IM-12 Structure
Size Price Availability Quantity
10mg USD 70 In stock
50mg USD 280 In stock
100mg USD 500 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

IM-12 is a potent and selective GSK-3β inhibitor with IC50 of 53 nM, which also enhances canonical Wnt signalling. IM-12 inhibits GSK-3β activity with IC50 of 3.8 μM and subsequently increases β-catenin concentration significantly in hNPCs. IM-12 significantly increased β-catenin levels. When used to treat human neural progenitor cells, IM-12 promoted neuronal differentiation resulting in an increase of neuronal cells. IM-12 has an IC50 of 53 nM in an in vitro binding assay, compared with 92 nM for SB-216763 in the same assay condition.

Cell Experiment
Cell lines ReNcell VM cells
Preparation method To measure viable cells, using CASY technology with the appropriate program to analyze 50-100 μL of cell suspension .Adding ReNcell VM cells are at a defined cell number and proliferated for 24 h. Then changing the medium to proliferation medium with added substances at indicated concentrations. Determining the cell number every 24 h. Exposing cells to the added drugs during the whole experiment, whereas changing the media every 24 h.
Concentrations 3 μM
Incubation time 72 hours
Animal Experiment
Animal models
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 377.41
Formula C22H20FN3O2
CAS Number 1129669-05-1
Purity >98%
Solubility DMSO 60 mg/mL
Ethanol 10 mg/mL
Storage at -20°C

Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells.
Schmöle AC, et al. Bioorg Med Chem. 2010 Sep 15;18(18):6785-95. PMID: 20708937.

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Abmole Inhibitor Catalog 2017

Keywords: IM-12 supplier, GSK-3, inhibitors

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