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iFSP1

Cat. No. M11314
iFSP1  Structure
Size Price Availability Quantity
10mg USD 60  USD60 In stock
50mg USD 265  USD265 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

IFSP1 is an effective, selective and glutathione-independent inhibitor of ferroptosis Suppressor protein 1 (FSP1/AIFM2) with an EC50 value of 103 nM. IFSP1 can selectively induce iron death in Pfa1 cells and HT1080 cells with GPX4 knockout gene overexpressing FSP1.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 323.35
Formula C20H13N5
CAS Number 150651-39-1
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] Ara Jo, et al. Cell Death Dis. Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells

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Keywords: iFSP1 supplier, Ferroptosis, inhibitors

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