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Idebenone

Cat. No. M3400
Idebenone Structure
Synonym:

CV-2619

Size Price Availability Quantity
10mM*1mL in DMSO USD 60  USD60 In stock
10mg USD 55  USD55 In stock
25mg USD 80  USD80 In stock
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Quality Control
Biological Activity

Idebenone, a mitochondrial protector, has neuroprotective properties and can be used to study Alzheimer's disease, Huntington's disease, and can cross the blood-brain barrier. Idebenone (oxidized form) inhibited arachidonic acid enzyme metabolism in astrocyte homogenates (IC50=16.65 μM). Idebenone is a coenzyme Q10 analogue and antioxidant that induces apoptosis (apoptotic) in human dopaminergic neuroblastoma SHSY-5Y cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 338.44
Formula C19H30O5
CAS Number 58186-27-9
Purity >98%
Solubility DMSO 60 mg/mL
Storage at -20°C
References

[1] Nuri Gueven, et al. Idebenone: When an antioxidant is not an antioxidant

[2] Claudia B Catarino, et al. Real-World Clinical Experience With Idebenone in the Treatment of Leber Hereditary Optic Neuropathy

[3] Jialing Peng, et al. Idebenone attenuates cerebral inflammatory injury in ischemia and reperfusion via dampening NLRP3 inflammasome activity

[4] Aijuan Yan, et al. Idebenone Alleviates Neuroinflammation and Modulates Microglial Polarization in LPS-Stimulated BV2 Cells and MPTP-Induced Parkinson's Disease Mice

[5] Sausan Jaber, et al. Idebenone and neuroprotection: antioxidant, pro-oxidant, or electron carrier?

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