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Hederacolchiside-A1

Cat. No. M4117

All AbMole products are for research use only, cannot be used for human consumption.

Hederacolchiside-A1 Structure
Size Price Availability Quantity
5mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Hederacolchiside A1, isolated from Pulsatilla pulsatilla, induces apoptosis by regulating the PI3K/Akt/mTOR signaling pathway, thereby inhibiting the proliferation of tumor cells. Hederacolchiside A1 has anti-schistosomiasis activity and affects parasite viability in vivo and in vitro.

Chemical Information
Molecular Weight 897.10
Formula C47H76O16
CAS Number 106577-39-3
Form Solid
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Naixin Kang, et al. Antischistosomal Properties of Hederacolchiside A1 Isolated from Pulsatilla chinensis

[2] Yuanying Fang, et al. Synthesis and biological evaluation of Hederacolchiside A1 derivatives as anticancer agents

[3] Mao-Sheng Cheng, et al. Synthesis of beta-hederin and Hederacolchiside A1: triterpenoid saponins bearing a unique cytotoxicity-inducing disaccharide moiety

[4] Chantal Barthomeuf, et al. Inhibition of HUVEC tubulogenesis by hederacolchiside-A1 is associated with plasma membrane cholesterol sequestration and activation of the Ha-Ras/MEK/ERK cascade

[5] E Debiton, et al. In addition to membrane injury, an affinity for melanin might be involved in the high sensitivity of human melanoma cells to hederacolchiside A1

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Keywords: Hederacolchiside-A1 supplier, PI3K, inhibitors, activators

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