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HA130

Cat. No. M4964

HA130 Structure
Size Price Availability Quantity
5mg USD 110 In stock
10mg USD 150 In stock
50mg USD 480 In stock
100mg USD 800 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

HA130 instantaneously lowers plasma levels of LPA in mice after intravenous administration.HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 463.29
Formula C24H19BFNO5S
CAS Number 1229652-21-4
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells.
Zhang Y,et.al. J Immunol 2012 Oct 15;3914-24. PMID: 22962684.

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  Catalog
Abmole Inhibitor Catalog 2017




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