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GW627368X

Cat. No. M10180
GW627368X Structure
Synonym:

GW 627368

Size Price Availability Quantity
5mg USD 54  USD60 In stock
10mg USD 81  USD90 In stock
25mg USD 135  USD150 In stock
50mg USD 225  USD250 In stock
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Quality Control
Biological Activity

GW627368X is a novel, potent and selective competitive antagonist of prostanoid EP4 receptors with additional human TP receptor affinity. Oral administration of GW627368X showed significant tumor regression characterized by tumor reduction and induction of apoptosis. Reduction in prostaglandin E2 synthesis also led to reduced level of VEGF in plasma.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 544.62
Formula C30H28N2O6S
CAS Number 439288-66-1
Purity 99.91%
Solubility DMSO ≥ 10 mg/mL
Storage at -20°C
References

Molecular inhibition of prostaglandin E2 with GW627368X: Therapeutic potential and preclinical safety assessment in mouse sarcoma model
Sheetal Parida, et al. Cancer Biol Ther. 2015;16(6):922-32. PMID: 25894216.

Pharmacological brake-release of mRNA translation enhances cognitive memory
Carmela Sidrauski, et al. Elife. 2013 May 28;2:e00498. PMID: 23741617.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: GW627368X, GW 627368 supplier, Prostaglandin Receptor, inhibitors

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