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Glutinone

Cat. No. M17857
Glutinone Structure
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Biological Activity

Glutinone

Chemical Information
CAS Number 508-09-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xiaoyu Zha, et al. Open Life Sci. Identification of active compounds in Ophiopogonis Radix from different geographical origins by UPLC-Q/TOF-MS combined with GC-MS approaches

[2] Zikang Jiang, et al. RSC Adv. A review on the phytochemistry and pharmacology of the herb Scoparia dulcis L. for the potential treatment of metabolic syndrome

[3] Nadia Las Heras Etayo, et al. Plants (Basel). Ethnobotanical Research and Compilation of the Medicinal Uses in Spain and the Active Principles of Chiliadenus glutinosus (L.) Fourr. for the Scientific Validation of Its Therapeutic Properties

[4] Khaga Raj Sharma, et al. Phytother Res. Potent Insulin Secretagogue from Scoparia dulcis Linn of Nepalese Origin

[5] Benito Paulina Bermejo, et al. Biol Pharm Bull. Sesquiterpenes from Jasonia glutinosa: in vitro anti-inflammatory activity

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