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Cat. No. M9217
Givinostat Structure


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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Givinostat decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro. Givinostat reduces cytokines and protects islet β cells in vivo and in vitro. Treatment with Givinostat ≥500 nM is associated with significant inhibition of JS-1 cell proliferation (P<0.01). Also, the cell inhibition rate significantly differs between the group cotreated with Givinostat ≥250 nM plus LPS and the group without LPS treatment (same Givinostat concentration) (P<0.05).

Cell Experiment
Cell lines JS-1 cells
Preparation method JS-1 cell line is cultured in DMEM with 10% fetal bovine serum for 24 h, 30 wells of JS-1 cells are divided into two groups. In the first group, the culture medium is replaced by complete medium with final Givinostat (ITF-2357) concentrations of 0 nM, 125 nM, 250 nM, 500 nM, and 1000 nM. In the second group, Givinostat of relevant concentrations is added concomitantly with 100 nM of LPS solution. Three replicates are performed for each group. After inoculation at 37°C and 5% CO2 for 24 h, each well (100 μL) is incubated with 10 μL of CCK-8 solution. The plates are incubated at 37°C for 1 h and the absorbance is measured at 450 nm using a microplate reader.
Concentrations 0 nM, 125 nM, 250 nM, 500 nM, and 1000 nM
Incubation time 24 h
Animal Experiment
Animal models C57BL/6 mice
Dosages 10 mg/kg
Administration orally
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 421.49
Formula C24H27N3O4
CAS Number 497833-27-9
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C

Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation.
Wang YG, et al. World J Gastroenterol. 2015 Jul 21;21(27):8326-39. PMID: 26217084.

The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo.
Leoni F, et al. Mol Med. 2005 Jan-Dec;11(1-12):1-15. PMID: 16557334.

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Keywords: Givinostat, ITF2357 supplier, HDAC, inhibitors

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