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GDC-0994

Cat. No. M3668

GDC-0994 Structure
Size Price Availability
2mg USD 115 Out of stock
5mg USD 170 Out of stock
10mg USD 290 Out of stock
50mg USD 850 Out of stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

GDC-0994 potently inhibits phospho-p90RSK in tumor cells. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. GDC-0994 subsequently prevents ERK-dependent tumor cell proliferation and survival.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 439.85
Formula C21H18ClFN6O2
CAS Number 1453848-26-4
Purity >99%
Solubility DMSO
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: GDC-0994 supplier, ERK, inhibitors

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