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Galbelgin

Cat. No. M16976
Galbelgin Structure
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Galbelgin

Chemical Information
CAS Number 10569-12-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hyeji Shin, et al. Molecules. Lignans from Machilus thunbergii as Thymic Stromal Lymphopoietin Inhibitors

[2] Shiou-Ling Li, et al. Molecules. Phytochemical Investigation and Anti-Inflammatory Activity of the Leaves of Machilus japonica var. kusanoi

[3] Claire E Rye, et al. J Org Chem. Asymmetric synthesis of (+)-galbelgin, (-)-kadangustin J, (-)-cyclogalgravin and (-)-pycnanthulignenes A and B, three structurally distinct lignan classes, using a common chiral precursor

[4] Peng Xue, et al. J Asian Nat Prod Res. Total synthesis of (-)-talaumidin and (-)-galbelgin

[5] Hyoungsu Kim, et al. Org Lett. Stereoselective synthesis of tetrahydrofuran lignans via BF(3) x OEt(2)-promoted reductive deoxygenation/epimerization of cyclic hemiketal: synthesis of (-)-odoratisol C, (-)-futokadsurin A, (-)-veraguensin, (+)-fragransin A(2), (+)-galbelgin, and (+)-tal䲧盷Ỵ相

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Keywords: Galbelgin supplier, Lignans, inhibitors, activators

 
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