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Eudesmin

Cat. No. M16983
Eudesmin Structure
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Biological Activity

Eudesmin

Chemical Information
CAS Number 29106-36-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sang Ah Yi, et al. Molecules. Transcriptomics-Based Repositioning of Natural Compound, Eudesmin, as a PRC2 Modulator

[2] Ria Park, et al. Pharmaceutics. Tetrahydrofurofuranoid Lignans, Eudesmin, Fargesin, Epimagnolin A, Magnolin, and Yangambin Inhibit UDP-Glucuronosyltransferase 1A1 and 1A3 Activities in Human Liver Microsomes

[3] Min Yu, et al. Chem Biol Interact. Eudesmin exerts antitumor effects by down-regulating EZH2 expression in nasopharyngeal carcinoma cells

[4] Ki Hong Nam, et al. Biochem Biophys Res Commun. Eudesmin impairs adipogenic differentiation via inhibition of S6K1 signaling pathway

[5] Jai-Sing Yang, et al. Exp Ther Med. Eudesmin attenuates Helicobacter pylori-induced epithelial autophagy and apoptosis and leads to eradication of H. pylori infection

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