Free shipping on all orders over $ 500

Fargesin

Cat. No. M16984
Fargesin Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Fargesin

Chemical Information
CAS Number 68296-27-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jiansen Lu, et al. Arthritis Res Ther. Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathways

[2] Phan Thi Lam Hong, et al. Korean J Physiol Pharmacol. Flos magnoliae constituent fargesin has an anti-allergic effect via ORAI1 channel inhibition

[3] Ga-Eun Lee, et al. Int J Mol Sci. Fargesin Inhibits EGF-Induced Cell Transformation and Colon Cancer Cell Growth by Suppression of CDK2/Cyclin E Signaling Pathway

[4] Gang Wang, et al. Biochim Biophys Acta Mol Cell Biol Lipids. Fargesin alleviates atherosclerosis by promoting reverse cholesterol transport and reducing inflammatory response

[5] Ting Fu, et al. J Dermatol Sci. Fargesin inhibits melanin synthesis in murine malignant and immortalized melanocytes by regulating PKA/CREB and P38/MAPK signaling pathways

Related Lignans Products
Nyasol

Nyasol

Eudesmin

Eudesmin

Asarinin

Asarinin

Simulanol

Simulanol

Lyoniside

Lyoniside

  Catalog
Abmole Inhibitor Catalog




Keywords: Fargesin supplier, Lignans, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.