FBA-IN-1 is a pioneer, covalent allosteric inhibitor of 1, 6-bisphosphate fructoalbinase (CaFBA) from Candida albicans. FBA-IN 1 inhibited the growth of azole resistant strain 103 with MIC80 of 1 μg/mL.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Violacein is a bacterial metabolite originally isolated from C. violaceum that has antibacterial and antiprotozoal activities.
Cytidine-5'-monophospho-N-acetylneuraminic acid is a nucleotide.
MitoTEMPOL is a mitochondria-targeting superoxide dismutase mimetic that reduces mitochondrial O2- to H2O2.
The peptidoglycan (murein) sacculus is a unique and essential structural element in the cell wall of most bacteria.
L-Phenylalanyl-L-leucine is a leucine derivative.
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