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Estramustine phosphate sodium

Cat. No. M5626
Estramustine phosphate sodium Structure
Size Price Availability Quantity
10mg USD 80 In stock
50mg USD 125 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Estramustine phosphate sodium is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 564.35
Formula C23H30Cl2NNa2O6P
CAS Number 52205-73-9
Purity >99%
Solubility 7.8 mg/mL in DMSO
Storage at -20°C
References

Estramustine phosphate sodium in heavily pretreated patients with metastatic breast cancer: a retrospective consecutive case series.
Aurilio G, et al. Int J Clin Oncol. 2015 Feb;20(1):90-4. PMID: 24722887.

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  Catalog
Abmole Inhibitor Catalog 2017




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