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Epirubicin HCl

Cat. No. M5617
Epirubicin HCl Structure
Size Price Availability Quantity
10mg USD 75 In stock
50mg USD 250 In stock
100mg USD 400 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Epirubicin Hcl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 579.98
Formula C27H30ClNO11
CAS Number 56390-09-1
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Surface-modified Epirubicin-HCl liposomes and its in vitro assessment in breast cancer cell-line: MCF-7.
Gandhi R, et al. Drug Deliv. 2016 May;23(4):1152-62. PMID: 25586675.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Epirubicin HCl supplier, Topoisomerase, inhibitors

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