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DS-437

Cat. No. M8561
DS-437 Structure
Synonym:

DS437

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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

DS-437 is an analog of S-adenosyl methionine (SAM ), which inhibits protein arginine methyltransferases PRMT5 and PRMT7 (IC50 5.9 and 6 μM) with little interaction against a panel of 30 other human methyltransferases.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 397.45
Formula C15H23N7O4S
CAS Number 1674364-87-4
Purity >98%
Solubility DMSO 20 mg/mL
Storage at -20°C
References

[1] Tingbin Ma, et al. Protein arginine methyltransferase 7 modulates neuronal excitability by interacting with NaV1.9

[2] Yasuhiro Nagai, et al. PRMT5 Associates With the FOXP3 Homomer and When Disabled Enhances Targeted p185 erbB2/neu Tumor Immunotherapy

[3] David Smil, et al. Discovery of a Dual PRMT5-PRMT7 Inhibitor

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  Catalog
Abmole Inhibitor Catalog




Keywords: DS-437, DS437 supplier, PRMTs, inhibitors

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