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DS-437 is an analog of S-adenosyl methionine (SAM ), which inhibits protein arginine methyltransferases PRMT5 and PRMT7 (IC50 5.9 and 6 μM) with little interaction against a panel of 30 other human methyltransferases.
| Molecular Weight | 397.45 |
| Formula | C15H23N7O4S |
| CAS Number | 1674364-87-4 |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] David Smil, et al. Discovery of a Dual PRMT5-PRMT7 Inhibitor
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