Free shipping on all orders over $ 500

C7280948

Cat. No. M3783
C7280948 Structure
Size Price Availability Quantity
5mg USD 45  USD45 In stock
10mg USD 80  USD80 In stock
50mg USD 250  USD250 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

C7280948 is a sulfone inhibitor of PRMT1 (IC50 values 12.75 μM and 26.7 μM, respectively, methylated substrates for oligopeptides containing human histone H4 and non-histone Npl3 1-21 amino acids). PRMT inhibitors are a potential compound and interesting tool for cell biology. C7280948 is an effective tool for studying the epigenetic effects of PRMT1. PRMT1 is also involved in activation of estrogen and androgen receptors. PRMT1 is an essential component of the oncogenic transformation induced by the mixed line leukemia (MLL) complex, and thus may represent a new research direction in hormone-dependent cancers.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 276.35
Formula C14H16N2O2S
CAS Number 587850-67-7
Purity 100.00%
Solubility DMSO 35 mg/mL
Storage at -20°C
References

[1] Bissinger EM, et al. Bioorg Med Chem. Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1.

[2] Heinke R, et al. ChemMedChem. Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors.

Related PRMTs Products
GSK3368715 2HCl

GSK3368715 2HCl is a novel potent, orally active, reversible type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50 values of 3.1 nM, 48 nM, 1148 nM, 5.7 nM and 1.7 nM for PRMT1, PRMT3, PRMT4, PRMT6, PRMT8, respectively.

AMI-1 disodium salt

AMI-1 is a potent and selective, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50 values of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 is also a potent scavenger of NADPH-oxidase-derived superoxide.

HLCL-61 hydrochloride

HLCL-61 hydrochloride is a potent and selective, first-in-class protein arginine methyltransferase 5 (PRMT5) inhibitor.

MS049

MS049 is a potent and selective inhibitor of PRMT4,6 with IC50 values of 34 nM and 43 nM, respectively.

GSK3326595

GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 6.2 nM.

  Catalog
Abmole Inhibitor Catalog




Keywords: C7280948 supplier, PRMTs, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.