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EPZ015666

Cat. No. M4954
EPZ015666 Structure
Synonym:

GSK3235025

Size Price Availability Quantity
10mM*1mL in DMSO USD 110  USD110 In stock
2mg USD 65  USD65 In stock
5mg USD 100  USD100 In stock
10mg USD 150  USD150 In stock
25mg USD 300  USD300 In stock
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Quality Control
Biological Activity

EPZ015666 shows potent cellular activity that blocks symmetric dimethylation of SmD3 and inhibit proliferation of MCL cell lines (Z-138, Granta-519, Maver-1, Mino, and Jeko-1) with IC50 of 96-904 nM. EPZ015666 (200 mg/kg, p.o.) displays robust anti-tumor activity in MCL xenograft animal models.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 383.44
Formula C20H25N5O3
CAS Number 1616391-65-1
Purity 99.77%
Solubility DMSO 55 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: EPZ015666, GSK3235025 supplier, PRMTs, inhibitors

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