Free shipping on all orders over $ 500

Docetaxel Trihydrate

Cat. No. M5588
Docetaxel Trihydrate Structure
Size Price Availability Quantity
25mg USD 25  USD25 In stock
100mg USD 55  USD55 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Docetaxel trihydrate(Taxotere trihydrate), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.

Chemical Information
Molecular Weight 861.93
Formula C43H59NO17
CAS Number 148408-66-6
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hensley ML, et al. J Clin Oncol. Randomized phase III trial of gemcitabine plus docetaxel plus bevacizumab or placebo as first-line treatment for metastatic uterine leiomyosarcoma: an NRG Oncology/Gynecologic Oncology Group study.

Related Microtubule Products
P34cdc2 Kinase Fragment

P34cdc2 Kinase Fragment is associated with the completion of DNA replication in yeast mitosis.

Cemadotin

Cemadotin (LU103793) is an analogue of Dolastatin 15 which is naturally occurring cytotoxic peptides.

VLS-1488

VLS-1488 is an orally active KIF18A inhibitor that inhibits KIF18A microtubule-dependent ATPase activity with an IC50 value of 0.016 μM.

ENMD-1198

ENMD-1198 (IRC-110160), an orally active microtubule destabilizing agent, is a 2-methoxyestradiol analogue with antiproliferative and antiangiogenic activity.

Tubulin/JAK2-IN-1

Tubulin/JAK2-IN-1 is a dual inhibitor of Janus kinase 2 (JAK2) and microtubule.

  Catalog
Abmole Inhibitor Catalog




Keywords: Docetaxel Trihydrate supplier, Microtubule, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.