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Deoxyartemisinin

Cat. No. M10424
Deoxyartemisinin Structure
Synonym:

Deoxy Artemisinin

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Quality Control & Documentation
Biological Activity

Deoxyartemisinin

Chemical Information
Molecular Weight 266.33
Formula C15H22O4
CAS Number 72826-63-2
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] M S Nair, et al. J Ethnopharmacol. Artemisia annua L. extracts inhibit the in vitro replication of SARS-CoV-2 and two of its variants

[2] Chunqing Fu, et al. ACS Omega. Oral Bioavailability Comparison of Artemisinin, Deoxyartemisinin, and 10-Deoxoartemisinin Based on Computer Simulations and Pharmacokinetics in Rats

[3] M S Nair, et al. bioRxiv. Artemisia annua L. extracts inhibit the in vitro replication of SARS-CoV-2 and two of its variants

[4] Farzana Sabir, et al. Z Naturforsch C J Biosci. Bioconversion of artemisinin to its nonperoxidic derivative deoxyartemisinin through suspension cultures of Withania somnifera Dunal

[5] Ahmed M Galal, et al. J Nat Prod. Deoxyartemisinin derivatives from photooxygenation of anhydrodeoxydihydroartemisinin and their cytotoxic evaluation

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