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Deapio-platycodin-D

Cat. No. M4484
Deapio-platycodin-D Structure
Synonym:

Desapioplatycodin D

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10mg USD 280  USD280 1-2 Weeks
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Quality Control & Documentation
Biological Activity

Deapio-platycodin-D is extracted from Platycodon grandiforus.

Chemical Information
Molecular Weight 1092.32
Formula C52H84O24
CAS Number 78763-58-3
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chi Zhang, et al. Components study on antitussive effect and holistic mechanism of Platycodonis Radix based on spectrum-effect relationship and metabonomics analysis

[2] Jinqian Yu, et al. A strategy based on isocratic and linear-gradient high-speed counter-current chromatography for the comprehensive separation of platycosides from Platycodi radix

[3] Xiao-Qing Ma, et al. Influence of sulfur fumigation on glycoside profile in Platycodonis Radix (Jiegeng)

[4] Jin-Jun Shan, et al. Effects of Gancao on pharmacokinetic profiles of platycodin D and deapio-platycodin D in Jiegeng

[5] Wei Li, et al. Response surface methodology to optimize enzymatic preparation of Deapio-Platycodin D and Platycodin D from Radix Platycodi

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