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D-64131

Cat. No. M3755
D-64131 Structure
Size Price Availability Quantity
10mg USD 95 In stock
50mg USD 380 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

D-64131 is cytotoxic and inhibits tumor cell proliferation in vitro (IC50 = 74 nM). D-64131 prevents growth of tumor models in mice following oral administration in vivo.D-64131 has significant potential in cancer treatment.D-64131 and analogues have the potential to be developed for cancer therapy, replacing or supplementing standard therapy regimens with tubulin-targeting drugs from natural sources.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 251.28
Formula C16H13NO2
CAS Number 74588-78-6
Purity >98%
Solubility DMSO 100 mM
Ethanol 20 mM
Storage at -20°C
References

Indolobenzazepin-7-ones and 6-, 8-, and 9-membered ring derivatives as tubulin polymerization inhibitors: synthesis and structure--activity relationship studies.
Putey A, et al. J Med Chem. 2009 Oct 8;52(19):5916-25. PMID: 19743863.

2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors.
Beckers T, et al. Cancer Res. 2002 Jun 1;62(11):3113-9. PMID: 12036922.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: D-64131 supplier, Microtubule, inhibitors

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