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Crolibulin

Cat. No. M9010
Crolibulin Structure
Synonym:

EPC2407; crinobulin

Size Price Availability
5mg USD 560 4-7 Days
10mg USD 820 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Crolibulin is a small molecule tubulin polymerization inhibitor. Microtubulin inhibitor Crolibulin (EPC2407) binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of tubulin into microtubules, which may result in cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. Crolibulin also disrupts tumor neovascularization, which may result in a reduction in tumor blood flow and tumor hypoxia and ischemic necrosis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 417.26
Formula C18H17BrN4O3
CAS Number 1000852-17-4
Purity >98%
Solubility DMSO: ≥ 90 mg/mL (Need warming and ultrasonic)
Storage at -20°C
References

Discovery and Optimization of Novel 5-Indolyl-7-arylimidazo[1,2-a]pyridine-8-carbonitrile Derivatives as Potent Antitubulin Agents Targeting Colchicine-binding Site.
Zhai X, et al. Sci Rep. 2017 Feb 27;7:43398. PMID: 28240326.

Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer.
Kalmuk J, et al. Oncotarget. 2015 Sep 15;6(27):24376-92. PMID: 26203773.

Chromenes: potential new chemotherapeutic agents for cancer.
Patil SA, et al. Future Med Chem. 2013 Sep;5(14):1647-60. PMID: 24047270.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Crolibulin, EPC2407; crinobulin supplier, Microtubule, inhibitors

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