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Corylifol A

Cat. No. M5018
Corylifol A Structure
Size Price Availability Quantity
5mg USD 300 In stock
10mg USD 480 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Corylifol A showed an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 value of 0.81 ± 0.15 uM, also inhibited STAT3 phosphorylation induced by IL-6 in Hep3B cells.Corylifol A inhibited SARA PLpro in a dose-dependent manner with IC50 ranging between 4.2 and 38.4 μM

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 390.47
Formula C25H26O4
CAS Number 775351-88-7
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia.
Kim DW,et.al. J Enzyme Inhib Med Chem. 2014 Feb;59-63. PMID: 23323951.

Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation.
Lee SW,et.al. Planta Med. 2012 Jun;903-6. PMID: 22573369.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Corylifol A supplier, STAT, inhibitors

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