Corylifol A showed an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 value of 0.81 ± 0.15 uM, also inhibited STAT3 phosphorylation induced by IL-6 in Hep3B cells.Corylifol A inhibited SARA PLpro in a dose-dependent manner with IC50 ranging between 4.2 and 38.4 μM
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||10 mM in DMSO|
Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia.
Kim DW,et.al. J Enzyme Inhib Med Chem. 2014 Feb;59-63. PMID: 23323951.
Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation.
Lee SW,et.al. Planta Med. 2012 Jun;903-6. PMID: 22573369.
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