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Corosolic acid is a pentacyclic triterpene acid found in Lagerstroemia speciosa, has antidiabetic, anti-inflammatory, antiproliferative, and protein kinase C inhibition activity. Corosolic acid displayed antagonistic activity against the phorbol ester-induced morphological modification of K-562 leukemic cells. Corosolic acid induced apoptosis in CT-26 cells, mediated by the activation of caspase-3. It inhibited the proliferation and tube formation of human umbilical vein endothelial cells and human dermal lymphatic microvascular endothelial cells, decreased the proliferation and migration of human umbilical vein endothelial cells stimulated by angiopoietin-1.
In vivo, A mouse colon carcinoma CT-26 animal model was employed to determine the in vivo anti-angiogenic and anti-lymphangiogenic effects of corosolic acid.
| Molecular Weight | 472.7 |
| Formula | C30H48O4 |
| CAS Number | 4547-24-4 |
| Solubility (25°C) | DMSO 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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