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CNX-1351

Cat. No. M3730
CNX-1351 Structure
Size Price Availability Quantity
5mg USD 105 In stock
10mg USD 200 In stock
50mg USD 640 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

CNX-1351 potently inhibited PI3Kα and was 20−400 times less potent against β, γ, and δ. CNX-1351 inhibits PI3Kα signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX-1351 inhibits growth of cells dependent on PI3Kα. CNX-1351 also inhibits PI3Kα signaling in vivo and bonds to p110α.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 573.71
Formula C30H35N7O3S
CAS Number 1276105-89-5
Purity >98%
Solubility DMSO
Storage at -20°C
References

Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kα.
Nacht M, et al. J Med Chem. 2013 Feb 14;56(3):712-21. PMID: 23360348.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: CNX-1351 supplier, PI3K, inhibitors

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