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CLP290

Cat. No. M9423
CLP290 Structure
Synonym:

CLP-290

Size Price Availability Quantity
10mg USD 155 In stock
25mg USD 275 In stock
50mg USD 445 In stock
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Quality Control
Biological Activity

CLP290 is a novel, orally available KCC2 modulator, highly selective for KCC2 over related Cl- transporters. CLP290 can significantly lower blood arginine-vasopressin (AVP) and glucose levels in STZ rats.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 404.46
Formula C19H21FN4O3S
CAS Number 1181083-81-7
Purity 98.09%
Solubility DMSO ≥ 25 mg/mL
Storage at -20°C
References

Excitatory GABAergic Action and Increased Vasopressin Synthesis in Hypothalamic Magnocellular Neurosecretory Cells Underlie the High Plasma Level of Vasopressin in Diabetic Rats.
Kim YB, et al. Diabetes. 2018 Mar;67(3):486-495. PMID: 29212780.

Enhancing KCC2 function counteracts morphine-induced hyperalgesia.
Ferrini F, et al. Sci Rep. 2017 Jun 20;7(1):3870. PMID: 28634406.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: CLP290, CLP-290 supplier, Potassium Channel, inhibitors

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