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Citronellol

Cat. No. M11183
Citronellol Structure
Synonym:

Dihydrogeraniol, (±)-β-Citronellol

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1g USD 55  USD55 In stock
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Biological Activity

Citronellol ((±)-Citronellol) is a monoterpenoid compound isolated from cephalic geraniums. Citronellol ((±)-Citronellol induce necrotizing apoptosis in tumor cells by upregulating TNF-α, RIP1/RIP3 activity, downregulating caspase-3/caspase-8 activity, and increasing aggregation of reactive oxygen species (ROS).

Chemical Information
Molecular Weight 156.27
Formula C10H20O
CAS Number 106-22-9
Form Liquid
Solubility (25°C) Water ≥ 20 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Guozhen Jiang, et al. Metab Eng. A "push-pull-restrain" strategy to improve citronellol production in Saccharomyces cerevisiae

[2] Mara Rosa Pino-Otn, et al. J Environ Manage. Impact of citronellol on river and soil environments using non-target model organisms and natural populations

[3] Lina Hagvall, et al. Contact Dermatitis. Patch testing with purified and oxidized citronellol

[4] Daniele Silva, et al. Int J Mol Sci. (R)-(+)-β-Citronellol and (S)-(-)-β-Citronellol in Combination with Amphotericin B against Candida Spp

[5] Yamini Sharma, et al. Med Mycol. β-citronellol alters cell surface properties of Candida albicans to influence pathogenicity related traits

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Keywords: Citronellol, Dihydrogeraniol, (±)-β-Citronellol supplier, ROS, inhibitors, activators

 
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