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Cinobufagin

Cat. No. M4340
Cinobufagin Structure
Synonym:

NSC90325

Size Price Availability Quantity
20mg USD 320 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans, it has similar effects to digitalis and is used in traditional Chinese medicine. Cinobufagin has been shown to have clinical applications in cancer treatment as well as immunomodulatory and analgesic properties. Cinobufagin induces apoptosis of osteosarcoma cells through inactivation of Notch signaling. Cinobufagin induces autophagy-mediated cell death in human osteosarcoma U2OS cells through the ROS/JNK/p38 signaling pathway.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 442.55
Formula C26H34O6
CAS Number 470-37-1
Purity >98%
Solubility DMSO
Storage at -20°C
References

Cinobufagin induces apoptosis of osteosarcoma cells through inactivation of Notch signaling.
Cao Y, et al. Eur J Pharmacol. 2017 Jan 5;794:77-84. PMID: 27845066.

Cinobufagin induces autophagy-mediated cell death in human osteosarcoma U2OS cells through the ROS/JNK/p38 signaling pathway.
Ma K, et al. Oncol Rep. 2016 Jul;36(1):90-8. PMID: 27176794.

Inhibitory effect of bufalin and cinobufagin on steroidogenesis via the activation of ERK in human adrenocortical cells.
Kau MM, et al. Br J Pharmacol. 2012 Mar;165(6):1868-1876. PMID: 21913902.

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Keywords: Cinobufagin, NSC90325 supplier, JNK, inhibitors

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