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Cinnamyl coumarate

Cat. No. M17408
Cinnamyl coumarate Structure
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Biological Activity

Cinnamyl coumarate

Chemical Information
CAS Number 115610-30-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Adullah Alotaibi, et al. Molecules. Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana

[2] Xinyu Liu, et al. Plant J. Rewired phenolic metabolism and improved saccharification efficiency of a Zea mays cinnamyl alcohol dehydrogenase 2 (zmcad2) mutant

[3] Chen Zhang, et al. J Biotechnol. Characterization, functional analysis and application of 4-Coumarate: CoA ligase genes from Populus trichocarpa

[4] Jack P Wang, et al. Front Plant Sci. Enzyme-Enzyme Interactions in Monolignol Biosynthesis

[5] Ahmed M A Abd El-Mawla, et al. Nat Prod Res. Cinnamyl alcohols and methyl esters of fatty acids from Wedelia prostrata callus cultures

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