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Cichoric-Acid

Cat. No. M4354
Cichoric-Acid Structure
Synonym:

Cichoric acid; Dicaffeoyltartaric acid

Size Price Availability Quantity
20mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Cichoric Acid is a natural compound with antioxidant activity.

Chemical Information
Molecular Weight 474.37
Formula C22H18O12
CAS Number 6537-80-0
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Qi Wang, et al. Cichoric Acid Ameliorates Monosodium Urate-Induced Inflammatory Response by Reducing NLRP3 Inflammasome Activation via Inhibition of NF- k B Signaling Pathway

[2] Xiaoqin Ding, et al. Chicoric Acid Ameliorates Nonalcoholic Fatty Liver Disease via the AMPK/Nrf2/NF κ B Signaling Pathway and Restores Gut Microbiota in High-Fat-Diet-Fed Mice

[3] Agata Jabłońska-Trypuć, et al. Cichoric acid attenuates the toxicity of mesotrione. Effect on in vitro skin cell model

[4] Zhuoying Luo, et al. Cichoric acid from witloof inhibit misfolding aggregation and fibrillation of hIAPP

[5] Qing-Bo Lu, et al. Chicoric acid prevents PDGF-BB-induced VSMC dedifferentiation, proliferation and migration by suppressing ROS/NFκB/mTOR/P70S6K signaling cascade

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Keywords: Cichoric-Acid, Cichoric acid; Dicaffeoyltartaric acid supplier, ROS, inhibitors, activators


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