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Cevipabulin

Cat. No. M4975
Cevipabulin Structure
Synonym:

TTI-237

Size Price Availability Quantity
5mg USD 160 In stock
10mg USD 240 In stock
50mg USD 680 In stock
100mg USD 960 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

TTI-237 inhibited the binding of [(3)H]vinblastine to tubulin, but it caused a marked increase in turbidity development that more closely resembled the effect observed with docetaxel than that observed with vincristine. TTI-237 was active in vivo in several nude mouse xenograft models of human cancer, including LoVo human colon carcinoma and U87-MG human glioblastoma, when dosed i.v. or p.o.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 464.82
Formula C18H18ClF5N6O
CAS Number 849550-05-6
Purity >99%
Solubility DMSO 48mg/mL
Storage at -20°C
References

TTI-237: a novel microtubule-active compound with in vivo antitumor activity.
Beyer CF,et.al. Cancer Res 2008 Apr 1;2292-300. PMID: 18381436.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Cevipabulin, TTI-237 supplier, Microtubule, inhibitors

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