Calmidazolium chloride (R 24571) is a calmodulin antagonist that antagonizes CaM-dependent phosphodiesterase and calmodulin-induced activation of Ca2+-transporting ATPase in erythrocytes with IC50s of 0.15 and 0.35 μM, respectively. it is also used in anticancer studies. It binds CaMK with a Kd value of 3 nM.
| Molecular Weight | 687.7 |
| Formula | C31H23Cl7N2O |
| CAS Number | 57265-65-3 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | -20°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related CaMK Products |
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| Autocamtide 2
Autocamtide 2 is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). |
| Syntide 2
Syntide 2, a Ca2+- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected. |
| Autocamtide-2-related inhibitory peptide, myristoylated
Autocamtide-2-related inhibitory peptide, myristoylated is the myristoylated Autocamtide-2-related inhibitory peptide. |
| Calmodulin Dependent Protein Kinase Substrate
Calmodulin Dependent Protein Kinase Substrate is a Ca2+- and calmodulin (CaM)-dependent protein kinase (CaMK) substrate peptide. |
| Calmodulin Dependent Protein Kinase Substrate Analog
Calmodulin Dependent Protein Kinase Substrate Analog is a Ca2+- and calmodulin (CaM)-dependent protein kinase (CaMK) substrate peptide. |
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