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BSI-401

Cat. No. M2010
BSI-401 Structure
Size Price Availability Quantity
10mg USD 100 In stock
50mg USD 280 In stock
100mg USD 400 In stock
200mg USD 680 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

BSI-401 is a novel PARP-1 inhibitor with both oral bioavailability and strong antitumor potency. The IC50 of BSI-401 for all of the five pancreatic cancer cell lines was <15 μM. BSI-401 inhibits the growth of pancreatic cancer cells in vitro significantly. BSI-401 inhibits low-anchorage tumor cell colony formation. BSI-401 combined with oxaliplatin had potent synergistic antitumor activity (46 versus 132 days, P = 0.0063), and significantly (P = 0.0148) prevented acute oxaliplatin-induced neurotoxicity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 317.04
Formula C9H4INO4
CAS Number 142404-10-2
Purity >99%
Solubility DMSO
Storage at -20°C
References

Oral poly(ADP-ribose) polymerase-1 inhibitor BSI-401 has antitumor activity and synergizes with oxaliplatin against pancreatic cancer, preventing acute neurotoxicity.
Melisi D, et al. Clin Cancer Res. 2009 Oct 15;15(20):6367-77. PMID: 19808866.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BSI-401 supplier, PARP, inhibitors

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