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BN82002

Cat. No. M9518
BN82002 Structure
Synonym:

CDC25 Phosphatase Inhibitor I

Size Price Availability Quantity
5mg USD 105 In stock
10mg USD 145 In stock
50mg USD 440 In stock
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Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

BN82002 is a cell-permeable ortho-hydroxybenzylamino compound that displays anti-tumor properties. BN82002 inhibits the phosphatase activity of recombinant human CDC25A, B, and C in vitro. It impairs the proliferation of tumoral cell lines and increases cyclin-dependent kinase 1 inhibitory tyrosine phosphorylation. BN82002 delays cell cycle progression at G1-S, in S phase and at the G2-M transition in synchronized HeLa cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 359.42
Formula C19H25N3O4
CAS Number 396073-89-5
Purity >98.5%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

CDC25 Inhibition in Acute Myeloid Leukemia-A Study of Patient Heterogeneity and the Effects of Different Inhibitors.
Brenner AK, et al. Molecules. 2017 Mar 11;22(3). PMID: 28287460.

A novel synthetic inhibitor of CDC25 phosphatases: BN82002.
Brezak MC, et al. Cancer Res. 2004 May 1;64(9):3320-5. PMID: 15126376.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BN82002, CDC25 Phosphatase Inhibitor I supplier, Phosphatase, inhibitors

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