BMS-813160 is the first dual CCR2/CCR5 antagonist to enter clinical development for cardiovascular.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||25 mg/mL in DMSO|
A dual CCR2/CCR5 chemokine antagonist, BMS-813160? Evaluation of WO2011046916.
Norman P, et al. Expert Opin Ther Pat. 2011 Dec;21(12):1919-24. PMID: 21936726.
Ceforanide is a new cephalosporin with antibacterial activity and has a longer elimination half-life than any currently available cephalosporin.
Inositol Nicotinate is a formulation of niacin, which is also called vitamin B3, an essential human nutrient.
ND-630 is an ACC inhibitor of human ACC1 and ACC2 with IC50 values of 2.1 and 6.1 nM, respectively.
|D-Luciferin potassium salt
D-Luciferin potassium salt is the substrate of luciferases that catalyze the production of light in bioluminescent insects.
|ZD 7114 hydrochloride
ZD 7114 is a selective β3 adrenergic receptor agonist.
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