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BMS-813160

Cat. No. M6249
BMS-813160  Structure
Size Price Availability Quantity
5mg USD 320 In stock
10mg USD 500 In stock
50mg USD 1500 In stock
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Quality Control
  • Current batch:
  • Purity > 99%
  • COA
  • MSDS
Biological Activity

BMS-813160 is the first dual CCR2/CCR5 antagonist to enter clinical development for cardiovascular.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 484.64
Formula C25H40N8O2
CAS Number 1286279-29-5
Purity > 99%
Solubility 25 mg/mL in DMSO
Storage at -20°C
References

A dual CCR2/CCR5 chemokine antagonist, BMS-813160? Evaluation of WO2011046916.
Norman P, et al. Expert Opin Ther Pat. 2011 Dec;21(12):1919-24. PMID: 21936726.

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  Catalog
Abmole Inhibitor Catalog 2017




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