Free shipping on all orders over $ 500

BMS-707035

Cat. No. M1681

BMS-707035 Structure
Size Price Availability Quantity
10mg USD 240 In stock
50mg USD 720 In stock
100mg USD 1080 In stock
Bulk Inquiry?

Quality Control
Biological Activity

BMS-707035 is an HIV-1 integrase (IN) inhibitor. HIV-1 integrase (IN) represents a therapeutically advantageous viral target to treat HIV/AIDS in the clinic.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 410.42
Formula C17H19FN4O5S
CAS Number 729607-74-3
Purity >99%
Solubility DMSO
Storage at -20°C
References

Anti-infectives: clinical progress of HIV-1 integrase inhibitors.
Al-Mawsawi et al. Expert Opin Emerg Drugs. 2008 Jun;13(2):213-25. PMID: 18537517.

HIV-1 integrase inhibitors: an emerging clinical reality.
Dayam et al. Drugs R D. 2007;8(3):155-68. PMID: 17472411.

Related Integrase Products
Dolutegravir

S/GSK1349572 (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.

MK-2048

MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.

Raltegravir

Raltegravir (MK-0518) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM, respectively.

Elvitegravir

Elvitegravir (EVG) is a HIV integrase inhibitor with IC50 of 0.7 nM, 2.8 nM and 1.4 nM for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD, respectively.

S/GSK1349572

S/GSK1349572 (Dolutegravir) is a novel integrase inhibitor with an IC50 of 2.7 nM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BMS-707035 supplier, Integrase, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.