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Bictegravir

Cat. No. M9113
Bictegravir Structure
Synonym:

GS-9883

Size Price Availability Quantity
2mg USD 48  USD60 In stock
5mg USD 64  USD80 In stock
10mg USD 108  USD135 In stock
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Quality Control
Biological Activity

Bictegravir (GS-9883) is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 449.38
Formula C21H18F3N3O5
CAS Number 1611493-60-7
Purity 99.89%
Solubility DMSO: ≥ 60 mg/mL (Need ultrasonic and warming)
Storage at -20°C
References

[1] Chloe Orkin, et al. Fixed-dose combination bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir-containing regimens for initial treatment of HIV-1 infection: week 144 results from two randomised, double-blind, multicentre, phase 3, non-inferiority trials

[2] No authors listed. Bictegravir

[3] Emma D Deeks. Bictegravir/Emtricitabine/Tenofovir Alafenamide: A Review in HIV-1 Infection

[4] No authors listed. Bictegravir

[5] Vincenzo Spagnuolo, et al. Bictegravir

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Keywords: Bictegravir, GS-9883 supplier, Integrase, inhibitors

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