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FG-2216 (BIQ)

Cat. No. M8678
FG-2216 (BIQ) Structure
Synonym:

YM-311

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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

BIQ (FG-2216) is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme. FG-2216 is orally bioavailable and induced significant and reversible Epo induction in vivo. In male rhesus macaques, FG-2216 (60 mg/kg, p.o.), induces significant and reversible Epo induction, and induces a small elevation of HbF expression.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 280.66
Formula C12H9ClN2O4
CAS Number 223387-75-5
Purity >98%
Solubility DMSO: ≥ 30 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: FG-2216 (BIQ), YM-311 supplier, HIF, inhibitors

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