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Benzyl ferulate

Cat. No. M17414
Benzyl ferulate Structure
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Biological Activity

Benzyl ferulate (Oil)

Chemical Information
CAS Number 132335-97-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tatyana S Zhuk, et al. Bioorg Chem. Scope and limitations of biocatalytic carbonyl reduction with white-rot fungi

[2] Rita Valrio, et al. Bioprocess Biosyst Eng. Feeding strategies to optimize vanillin production by Amycolatopsis sp. ATCC 39116

[3] Chimengul Turghun, et al. Nat Prod Res. Phenolic glycosides from Nitraria sibirica leaves and their in vitro biological activities

[4] Shahzad Hussain, et al. Pak J Pharm Sci. Review: an exposition of medicinal preponderance of Moringa oleifera (Lank.)

[5] John H Grabber, et al. C R Biol. Genetic and molecular basis of grass cell-wall degradability. I. Lignin-cell wall matrix interactions

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