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BDA-366

Cat. No. M8920
BDA-366 Structure
Size Price Availability
5mg USD 450  USD450 4-7 Days
10mg USD 800  USD800 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

BDA-366 is a BCL2 BH4 domain antagonist, that binds BH4 with high affinity and selectivity. BDA-366 induces robust apoptosis in MM cell lines and primary MM cells by inducing BCL2 conformational change. Delivery of BDA-366 substantially suppressed the growth of human MM xenografts in NOD-scid/IL2Rγnull mice, without significant cytotoxic effects on normal hematopoietic cells or body weight. Combined BDA-366 and RAD001 treatment exhibits strong synergy against lung cancer in vivo.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 423.51
Formula C24H29N3O4
CAS Number 1821496-27-8
Purity >98%
Solubility DMSO
Storage at -20°C
References

[1] Han B, et al. Cancer Cell. Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy.

[2] Deng J, et al. Oncotarget. BCL2-BH4 antagonist BDA-366 suppresses human myeloma growth.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BDA-366 supplier, Bcl-2, inhibitors

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