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Bcl-2 B-cell lymphoma 2


Cat.No.  Name Information
M1637 ABT-263 ABT-263 (Navitoclax) is a potent, orally bioavailable inhibitor of the antiapoptotic Bcl-2 family members Bcl-2, Bcl-x (L), and Bcl-w.
M2017 ABT-199 (Venetoclax) ABT-199 is a highly potent, orally bioavailable and BCL-2 inhibitor.
M5273 S63845 S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor; binds human MCL1 with a Kd of 0.19 nM.
M10283 AZD-5991 Racemate AZD-5991 Racemate is a Mcl-1 inhibitor with an IC50 of <3 nM in FRET assay.
M9419 Bax inhibitor peptide V5 Bax inhibitor peptide V5 is a Bax-mediated apoptosis inhibitor.
M9095 Marinopyrrole A Marinopyrrole A (Maritoclax) is a novel and specific Mcl-1 inhibitor with an IC50 value of 10.1 μM.
M9044 MIK665 MIK665 is an inhibitor of induced myeloid leukemia cell differentiation protein (Mcl-1; Bcl2-L-3).
M8920 BDA-366 BDA-366 is a small molecule antagonist that specifically binds the BCL2 BH4 domain, and has the ability to convert anti-apoptotic BCL2 into a pro-apoptotic death molecule.
M7548 A-1331852 A-1331852 is an orally available BCL-XL selective inhibitor with a Ki of less than 10 pM.
M6256 BTSA1 BTSA1 is a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis. It effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells.
M5273 S63845 S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor; binds human MCL1 with a Kd of 0.19 nM.
M5266 BH3I-1 BH3I-1 is a Bcl-XL-BH3 domain interaction inhibitor with Ki of 2.4 μM (by fluorescence polarization ).It is a selective inhibitor of Bcl-2 family proteins.
M5226 UMI-77 UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family.
M4932 A-1210477 A-1210477 is an inhibitor of MCL-1 (Ki=0.45 nM in TR-FRET-binding assays), is a much weaker binder of BCL-2 (Ki=0.132 _mu_M) and BCL-XL(Ki>0.660 _mu_M).
M4775 Gambogic-acid Gambogic-acid is a caged xanthone that is derived from Garcinia hanburyi, which inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.
M4637 Jaceosidin Jaceosidin activates Bax and down-regulates Mcl-1 and c-FLIP expression.
M4521 Dehydrocorydaline Dehydrocorydaline is an alkaloid, it can regulate protein expression of Bax, Bcl-2.
M4385 Gossypol Gossypol has been known to exert a potential for anti-cancer, anti-inflammatory and other important therapeutic activities, gossypol binds and antagonizes anti-apoptotic effect of Bcl-2 family proteins.
M3757 Obatoclax Mesylate Obatoclax is an antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-XL, and Mcl-1 (KD = ~500 nM).
M3753 HA14-1 HA14-1 is a Bcl-2 inhibitor that is widely used for studies of apoptosis with IC50 of ~9 μM.
M2992 Sabutoclax Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
M2460 BM-1074 BM-1074 is a potent and efficacious Bcl-2/Bcl-xL inhibitor with Ki of <1 nM, inactive to Mcl-1.
M2430 BAM7 BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM.

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