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AZD5305

Cat. No. M10298
AZD5305 Structure
Synonym:

AZD-5305

Size Price Availability Quantity
5mg USD 270  USD300 In stock
10mg USD 414  USD460 In stock
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Quality Control
Biological Activity

AZD5305 is a potent and oral active, second-generation PARP (highly selective PARP1) inhibitor. AZD5305 showed highly effective and sustained anti-tumor activity in selected BRCAm xenograft and PDX in vivo models. At the same time, AZD5305 also showed benefits when used in combination with chemotherapy.

Customer Product Validations & Biological Datas
Source AZD5305
Method orally
Cell Lines BRCAm xenograft and PDX models
Concentrations 0.01~1mg/kg
Incubation Time -
Results AZD5305 shows benefit in combination with chemotherapy.
Source AZD5305
Method orally (PO)
Cell Lines BRCAm xenograft and PDX models
Concentrations 0.01~10mg/kg
Incubation Time 20, 31, 35 days
Results AZD5305 demonstrates high and sustained anti-tumour activity in a selection of BRCAm xenograft and PDX models in vivo.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 406.48
Formula C22H26N6O2
CAS Number 2589531-76-8
Purity 99.60%
Solubility
Storage at -20°C
References

The novel PARP1-selective inhibitor, AZD5305, is efficacious as monotherapy and in combination with standard of care chemotherapy in the in vivo preclinical models
Anna D. Staniszewska, et al. AACR. 2021 Jul;Volume 81, Issue 13, pp. 1270.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: AZD5305, AZD-5305 supplier, PARP, inhibitors

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