Free shipping on all orders over $ 500


Cat. No. M2419
AZD2461 Structure
Size Price Availability Quantity
5mg USD 110 In stock
10mg USD 170 In stock
50mg USD 520 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. AZD2461 has an 80-fold increased Mdr1b expression on Olaparib-resistant KB1P tumor T6-28, without inhibition of Pgp. AZD2461 induces loss of 53BP1 expression in mice with KB1P tumors with short-term treatment. Long-term AZD2461 treatment is well tolerated and doubled the median relapse-free survival. Importantly, PARPi resistance was minimized by long-term treatment with the novel PARP inhibitor AZD2461, which is a poor P-glycoprotein substrate.

Customer Product Validations & Biological Datas
Source Cancer Res (2016). Figure 4. AZD2461
Method immunofluorescence
Cell Lines A549 cells
Concentrations 500 nmol/L
Incubation Time 1 hour
Results Unlike olaparib, which results in persistence of gH2AX following IR to the same degree as APLF knockdown, AZD2461 had no effect on gH2AX dynamics.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 395.43
Formula C22H22FN3O3
CAS Number 1174043-16-3
Purity >99%
Solubility DMSO 60 mg/mL
Storage at -20°C

Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors.
Jaspers JE,et al. Cancer Discov. 2013 Jan;3(1):68-81. PMID: 23103855.

Related PARP Products
BGP-15 2HCl

BGP-15 is a novel poly(ADP-ribose) polymerase inhibitor with an IC50 and a Ki of 120 μM and 57 μM, respectively.


Benzamide is an inhibitor of poly(ADP-ribose) polymerase with an IC50 of 3.3 μM.


Picolinamide is a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.

Niraparib (MK-4827) tosylate

Niraparib (MK-4827) tosylate is an excellent PARP1 and PARP2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively.


Daidzein is an inactive analogue of genistein, a tyrosine kinase inhibitor and an estrogen receptor activator.

Abmole Inhibitor Catalog 2017

Keywords: AZD2461 supplier, PARP, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.