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Ansamitocin P 3

Cat. No. M6292
Ansamitocin P 3 Structure
Synonym:

Antibiotic C 15003P3; Maytansinol butyrate

Size Price Availability Quantity
10mg USD 200 In stock
50mg USD 500 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Ansamitocin P-3 is a microtubule inhibitor, it is also a macrocyclic antitumor antibiotic. Ansamitocin P3 inhibits the proliferation of MCF-7, HeLa, EMT-6/AR1 and MDA-MB-231 cells in culture. Further, Ansamitocin P3 binds to purified tubulin in vitro with a dissociation constant Kd value of 1.3±0.7 µM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 635.14
Formula C32H43ClN2O9
CAS Number 66584-72-3
Purity >98%
Solubility 50 mM in DMSO
Storage at -20°C
References

Improvement of ansamitocin P-3 production by Actinosynnema mirum with fructose as the sole carbon source.
Li T, et al. Appl Biochem Biotechnol. 2015 Mar;175(6):2845-56. PMID: 25564203.

Enhancement of ansamitocin P-3 production in Actinosynnema pretiosum by a synergistic effect of glycerol and glucose.
Gao Y, et al. J Ind Microbiol Biotechnol. 2014 Jan;41(1):143-52. PMID: 24174216.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ansamitocin P 3, Antibiotic C 15003P3; Maytansinol butyrate supplier, Microtubule, inhibitors

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