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Ansamitocin P 3

Cat. No. M6292
Ansamitocin P 3 Structure
Synonym:

Antibiotic C 15003P3; Maytansinol butyrate

Size Price Availability Quantity
5mg USD 140  USD140 In stock
10mg USD 200  USD200 In stock
25mg USD 310  USD310 In stock
50mg USD 480  USD480 In stock
100mg USD 610  USD610 In stock
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Quality Control & Documentation
Biological Activity

Ansamitocin P-3 is a microtubule inhibitor, it is also a macrocyclic antitumor antibiotic. Ansamitocin P3 inhibits the proliferation of MCF-7, HeLa, EMT-6/AR1 and MDA-MB-231 cells in culture. Further, Ansamitocin P3 binds to purified tubulin in vitro with a dissociation constant Kd value of 1.3±0.7 µM.

Chemical Information
Molecular Weight 635.14
Formula C32H43ClN2O9
CAS Number 66584-72-3
Solubility (25°C) 50 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Li T, et al. Appl Biochem Biotechnol. Improvement of ansamitocin P-3 production by Actinosynnema mirum with fructose as the sole carbon source.

[2] Gao Y, et al. J Ind Microbiol Biotechnol. Enhancement of ansamitocin P-3 production in Actinosynnema pretiosum by a synergistic effect of glycerol and glucose.

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Keywords: Ansamitocin P 3, Antibiotic C 15003P3; Maytansinol butyrate supplier, Microtubule, inhibitors, activators


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